Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 17/20 | 1.00 |
| ▸ | WRN | Q14191 | 4/20 | 0.78 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.76 |
| ▸ | HTT | P42858 | 4/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | GAA | P10253 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.76 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.76 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.76 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20659647 | 0.88 | BLM (1.00) | BLMWRNMCL1HTTKDM4E | |
| SCHEMBL29602870 | 0.88 | BLM (1.00) | BLMWRNMCL1HTTKDM4E | |
| SCHEMBL24232837 | 0.83 | BLM (0.80) | BLMWRNMCL1HTTKDM4E | |
| SCHEMBL11865712 | 0.83 | CA1 (0.71) | BLMWRNHTTSMN1; SMN2RAB9A | |
| SCHEMBL24233015 | 0.83 | BLM (0.77) | BLMWRNMCL1HTTKDM4E | |
| SCHEMBL24232825 | 0.83 | BLM (0.76) | BLMWRNMCL1HTTKDM4E | |
| SCHEMBL24233115 | 0.81 | BLM (0.69) | BLMWRNMCL1HTTKDM4E | |
| SCHEMBL24233005 | 0.78 | BLM (0.76) | BLMWRNMCL1HTTKDM4E | |
| SCHEMBL16628086 | 0.78 | KDR (0.68) | BLMPOLBKMT2AMEN1RAB9A | |
| SCHEMBL24233029 | 0.78 | HTT (1.00) | BLMWRNMCL1HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022026823-A1 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2022-02-03 | — | — | WO | disclosed |