SCHEMBL24233248

SCHEMBL24233248

CC1(C)C(NC(=O)c2ccc(N3CCC(C=O)CC3)nc2)C(C)(C)C1Oc1ccc(C#N)c(Cl)c1

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 20/20 0.62
CRBN Q96SW2 4/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26115617 1.00 AR (0.62) ARCRBN
SCHEMBL25937180 1.00 AR (0.62) ARCRBN
SCHEMBL19600787 0.92 AR (0.64) ARCRBN
SCHEMBL24379225 0.91 AR (0.54) ARCRBN
SCHEMBL20046374 0.91 AR (0.59) ARCRBN
SCHEMBL26116944 0.91 AR (0.64) ARCRBN
SCHEMBL25141463 0.91 AR (0.64) ARCRBN
SCHEMBL30588309 0.91 AR (0.64) ARCRBN
SCHEMBL25141595 0.90 AR (0.62) ARCRBN
SCHEMBL30588422 0.90 AR (0.62) ARCRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4499628-A1 2,4-DIOXOTETRAHYDROPYRIMIDINYL DERIVATIVES AS DEGRONS IN PROTACS GlaxoSmithKline Intellectual Property Development Limited (GB) 2025-02-05 EP disclosed
WO-2024054953-A1 HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE HALDA THERAPEUTICS OPCO, INC. (US) 2024-03-14 WO disclosed
WO-2023180388-A1 2,4-DIOXOTETRAHYDROPYRIMIDINYL DERIVATIVES AS DEGRONS IN PROTACS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2023-09-28 WO disclosed
WO-2022025640-A1 COMPOUND FOR INHIBITING OR DISINTEGRATING ANDROGEN RECEPTOR, AND PHARMACEUTICAL USE THEREOF 한국화학연구원 2022-02-03 WO disclosed