⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2020938 | 0.76 | — | — | |
| SCHEMBL20054228 | 0.73 | — | — | |
| SCHEMBL587516 | 0.73 | — | — | |
| SCHEMBL583517 | 0.73 | — | — | |
| SCHEMBL17790346 | 0.73 | — | — | |
| SCHEMBL2020934 | 0.73 | — | — | |
| SCHEMBL9608890 | 0.73 | GAA (0.44) | — | |
| SCHEMBL14625212 | 0.73 | — | — | |
| SCHEMBL22090233 | 0.73 | — | — | |
| SCHEMBL21721701 | 0.72 | GRN (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858930-B2 | Fused bicyclic RAF inhibitors and methods for use thereof | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2024-01-02 | — | — | US | disclosed |
| US-20220033398-A1 | FUSED BICYCLIC RAF INHIBITORS AND METHODS FOR USE THEREOF | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE | 2022-02-03 | — | — | US | disclosed |