Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ibufenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 0.60 |
| ▸ | PTGS2 known ✓ | P35354 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.60 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.60 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | ALB | P02768 | 1/20 | 0.60 |
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | RARB | P10826 | 1/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.60 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.60 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.60 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibufenac SCHEMBL503595 | 0.98 | PTGS1 (0.58) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| Ibufenac SCHEMBL2528574 | 0.98 | PTGS1 (0.58) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| Ibufenac SCHEMBL11571262 | 0.98 | PTGS1 (0.58) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL25146345 | 0.94 | PTGS1 (0.62) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| Ibuprofen SCHEMBL8210899 | 0.88 | PTGS1 (0.83) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL28872737 | 0.85 | ANPEP (0.55) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| Ibuprofen SCHEMBL28254474 | 0.85 | PTGS1 (0.78) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL9577298 | 0.83 | PTGS1 (0.56) | PTGS1PTGS2LMNACYP2C9AKR1C3 | |
| SCHEMBL5566579 | 0.83 | ANPEP (0.62) | ANPEPENPEPCA2CAMK2A | |
| Hydrogen Peroxide SCHEMBL9581174 | 0.83 | PTGS1 (0.64) | PTGS1PTGS2LMNACYP2C9AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 12570 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4525870-A1 | METHODS OF TREATING CUSHING'S SYNDROME AND LIVER DISORDERS, AND OF REDUCING LIVER TOXICITY OF OTHER DRUGS ADMINISTERED TO A PATIENT | Corcept Therapeutics Incorporated (US) | 2025-03-26 | — | — | EP | claimed |
| US-20250025435-A1 | CO-CRYSTALS OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, LYSINE AND GABAPENTIN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE | DOMPE' FARMACEUTICI SPA (IT) | 2025-01-23 | — | — | US | claimed |
| CN-119317433-A | Methods for treating cushing's syndrome and liver disease and reducing hepatotoxicity of other drugs taken by patients | 科赛普特治疗学股份有限公司 | 2025-01-14 | — | — | CN | claimed |
| EP-4470565-A1 | METHOD FOR PREVENTING OR TREATING DISEASE OR DISORDER ASSOCIATED WITH ANTINEOPLASTIC AGENT | OnQuality Pharmaceuticals China Ltd. (CN) | 2024-12-04 | — | — | EP | claimed |
| US-RE50218-E1 | Non-steroidal anti-inflammatory ophthalmic compositions | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2024-11-26 | — | — | US | claimed |
| EP-4423057-A1 | CO-CRYSTALS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, LYSINE AND GABAPENTIN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE | Dompe' Farmaceutici SpA (IT) | 2024-09-04 | — | — | EP | claimed |
| CN-118475555-A | Co-crystals of non-steroidal anti-inflammatory drugs, lysine and gabapentin, pharmaceutical compositions and medical uses thereof | 导博药物公司 | 2024-08-09 | — | — | CN | claimed |
| US-20240245659-A1 | Methods of Treating Cushing's Syndrome and Liver Disorders, and of Reducing Liver Toxicity of Other Drugs Administered to a Patient | CORCEPT THERAPEUTICS INCORPORATED (US) | 2024-07-25 | — | — | US | claimed |
| CN-118340907-A | Polymer conjugates comprising bioactive agents | 波利艾克蒂瓦有限公司 | 2024-07-16 | — | — | CN | claimed |
| US-20240200072-A1 | Allogeneic Cartilage Regeneration | Tarachon, LLC (US) | 2024-06-20 | — | — | US | claimed |
| WO-1984000490-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1984-02-16 | — | — | WO | claimed |
| US-4376767-A | ANTIBIOTICS AND PHARMACEUTICALS | MERCK & CO., INC. (US) | 1983-03-15 | — | — | US | claimed |
| EP-0072462-A2 | Pharmaceutical preparations | Toko Yakuhin Industry Co., Ltd. (JP) | 1983-02-23 | — | — | EP | claimed |
| EP-0055870-A1 | Pyridylmethyl esters of selected bio-affecting carboxylic acids, process for preparing and pharmaceutical composition comprising the same | MERCK & CO. INC. (US) | 1982-07-14 | — | — | EP | claimed |
| EP-0051278-A1 | Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1982-05-12 | — | — | EP | claimed |
| EP-0039051-A2 | Mannich-base hydroxamic acid prodrugs for the improved bioavailability of non-steroidal anti-inflammatory agents, a process for preparing and a pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1981-11-04 | — | — | EP | claimed |
| US-4279926-A | PHENYL ALKANOIC ACID SALT OF AN AMINO ACID | SPA-SOCIETA PRODOTTI ANTIBIOTICI S.P.A. (IT) | 1981-07-21 | — | — | US | claimed |
| US-4264582-A | IN CONJUNCTION WITH A PHOSPHONATE COMPOUND | THE PROCTER & GAMBLE COMPANY (US) | 1981-04-28 | — | — | US | claimed |
| US-4163783-A | ACID AND A BIS/2-PYRIDYL-1-OXIDE/DISULFIDE | KLEIN ROBERT W | 1979-08-07 | — | — | US | claimed |
| US-4152430-A | ANTIINFLAMMATORY AGENTS | WILLIAM H. RORER, INC. (US) | 1979-05-01 | — | — | US | claimed |