Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | PRKDC | P78527 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24248383 | 0.92 | ATR (0.41) | ATRATMPRKDCGSK3B | |
| SCHEMBL3056643 | 0.87 | ATR (0.53) | ATRATMPRKDCGSK3B | |
| SCHEMBL3060462 | 0.83 | ATR (0.54) | ATRATMPRKDCGSK3B | |
| SCHEMBL3060463 | 0.83 | ATR (0.54) | ATRATMPRKDCGSK3B | |
| SCHEMBL3065665 | 0.83 | ATR (0.54) | ATRATMPRKDCGSK3B | |
| SCHEMBL24681416 | 0.82 | ATR (0.54) | ATRATMPRKDCGSK3B | |
| SCHEMBL24248345 | 0.82 | ATR (0.48) | ATRATMPRKDCGSK3B | |
| SCHEMBL24681417 | 0.82 | ATR (0.48) | ATRATMPRKDCGSK3B | |
| SCHEMBL3049412 | 0.80 | ATR (0.54) | ATRATMPRKDCGSK3B | |
| SCHEMBL3057660 | 0.80 | ATR (0.54) | ATRATMPRKDCGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4059932-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2022-09-21 | — | — | EP | disclosed |
| EP-3354650-B1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMA (US) | 2022-02-16 | — | — | EP | disclosed |