Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2418976 | 0.75 | JAK3 (0.44) | ALDH1A1KDM4ENPC1HTTRAB9A | |
| SCHEMBL26917154 | 0.75 | KMT2A (0.42) | ALDH1A1KDM4ENPC1HTTRAB9A | |
| SCHEMBL2425503 | 0.74 | KMT2A (0.45) | ALDH1A1KDM4ENPC1HTTRAB9A | |
| SCHEMBL2425813 | 0.73 | JAK3 (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7908942 | 0.72 | SMN1; SMN2 (0.36) | ALDH1A1KDM4ENPC1HTTRAB9A | |
| SCHEMBL3653218 | 0.69 | POLB (0.56) | ALDH1A1KDM4EHSD17B10TSHRNPC1 | |
| SCHEMBL3653216 | 0.69 | POLB (0.56) | ALDH1A1KDM4EHSD17B10TSHRNPC1 | |
| Tetrahydrofuran SCHEMBL25233102 | 0.68 | HTT (0.54) | ALDH1A1KDM4ENPC1HTTRAB9A | |
| Bromide SCHEMBL6990879 | 0.68 | HRH3 (0.47) | TSHRNPC1HTTRAB9ASMN1; SMN2 | |
| SCHEMBL2424404 | 0.68 | GRM4 (0.42) | NPC1HTTRAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |