Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16135651 | 0.88 | CLK4 (0.44) | CLK4DYRK1BNTRK2TYRO3FYN | |
| SCHEMBL16154658 | 0.86 | CLK4 (0.39) | CLK4DYRK1BNTRK2TYRO3FYN | |
| SCHEMBL16135661 | 0.74 | CLK4 (0.44) | CLK4DYRK1BNTRK2TYRO3FYN | |
| SCHEMBL16154664 | 0.72 | CLK4 (0.40) | CLK4DYRK1BNTRK2TYRO3FYN | |
| SCHEMBL24681043 | 0.69 | FYN (0.64) | FYN | |
| SCHEMBL16133539 | 0.69 | BRD4 (0.36) | BACE1BACE2MAP3K14TNIK | |
| SCHEMBL16135668 | 0.66 | CLK4 (0.59) | CLK4DYRK1BNTRK2TYRO3FYN | |
| SCHEMBL18113045 | 0.66 | PRKCI (0.49) | CLK4NTRK1FLT3GSK3BBRAF | |
| SCHEMBL13828402 | 0.64 | PIK3CD (0.57) | KDRBRAF | |
| SCHEMBL29871724 | 0.63 | CLK4 (0.49) | CLK4DYRK1BNTRK2TYRO3FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3954679-A2 | AMIDE COMPOUNDS FOR THE TREATMENT OF HIV INFECTIONS | Gilead Sciences, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |