Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12531180 | 1.00 | NR1H2 (0.41) | NR1H2CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL13482907 | 1.00 | NR1H2 (0.41) | NR1H2CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL20371561 | 0.88 | CHRM2 (0.41) | NR1H2CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL11917911 | 0.88 | CHRM2 (0.41) | NR1H2CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL10263362 | 0.86 | CHRM2 (0.40) | NR1H2CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL14947787 | 0.86 | CHRM2 (0.40) | NR1H2CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL18901856 | 0.86 | CHRM2 (0.40) | NR1H2CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL14230420 | 0.86 | CHRM2 (0.40) | NR1H2CHRM2CHRM1CHRM3DDB1 | |
| SCHEMBL14282112 | 0.85 | ITGB1 (0.40) | CHRM2CHRM1CHRM3DDB1CRBN | |
| SCHEMBL627060 | 0.85 | CHRM2 (0.39) | NR1H2CHRM2CHRM1CHRM3DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3536685-B1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS | PFIZER (US) | 2022-02-16 | — | — | EP | disclosed |