Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.66 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.66 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.66 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.66 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.66 |
| ▸ | FOLH1 | Q04609 | 7/20 | 0.62 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | IDE | P14735 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24250882 | 0.92 | F2 (0.66) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL4968230 | 0.89 | F2 (0.73) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL19751698 | 0.89 | F2 (0.73) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL19017236 | 0.89 | F2 (0.73) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL15216220 | 0.89 | F2 (0.73) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL26345911 | 0.88 | PRSS1 (0.73) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL26345858 | 0.88 | PRSS1 (0.71) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL19731548 | 0.88 | PRSS1 (0.71) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL15281582 | 0.88 | F2 (0.76) | F2PRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL15308981 | 0.88 | F2 (0.73) | F2PRSS1PRSS2PRSS3TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230140838-A9 | NOVEL ACTIVITY-BASED PROBES FOR NEUTROPHIL ELASTASE AND THEIR USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-05-04 | — | — | US | disclosed |
| US-20220050107-A1 | NOVEL ACTIVITY-BASED PROBES FOR NEUTROPHIL ELASTASE AND THEIR USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2022-02-17 | — | — | US | disclosed |