Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18386914 | 0.85 | EGFR (0.47) | EGFRALKKCNH2PTK2 | |
| SCHEMBL26101556 | 0.85 | EGFR (0.40) | EGFRALKPTK2EML4 | |
| SCHEMBL19089591 | 0.83 | EGFR (0.45) | EGFRPTK2 | |
| SCHEMBL19089590 | 0.83 | EGFR (0.46) | EGFRALKPTK2EML4 | |
| SCHEMBL21232360 | 0.81 | EGFR (0.41) | EGFRALKPTK2EML4 | |
| SCHEMBL22509168 | 0.81 | PTK2 (0.51) | EGFRALKKCNH2PTK2EML4 | |
| SCHEMBL22507940 | 0.81 | EGFR (0.41) | EGFRALKKCNH2PTK2EML4 | |
| SCHEMBL21232323 | 0.81 | EGFR (0.41) | EGFRALKEML4 | |
| SCHEMBL21232053 | 0.81 | EGFR (0.41) | EGFRALKKCNH2PTK2EML4 | |
| SCHEMBL22507877 | 0.81 | EGFR (0.44) | EGFRALKKCNH2PTK2EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022033455-A1 | TRIAZINE DERIVATIVE HAVING EGFR INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |