Sugi Predict

Sugi Predict / Compounds / SCHEMBL24252333

SCHEMBL24252333

SCHEMBL24252333

COc1ccc(CNc2nnc(C)c3cc(-c4cc(Cl)c(CCOC5CCCCO5)cc4OC)ccc23)c(OC)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ CYP1A2 P05177 16/20 0.39
▸ CYP3A4 P08684 16/20 0.39
▸ CYP2C19 P33261 15/20 0.39
▸ TSHR P16473 13/20 0.39
▸ ALDH1A1 P00352 12/20 0.39
▸ CYP2C9 P11712 11/20 0.39
▸ CLK4 Q9HAZ1 8/20 0.39
▸ LMNA P02545 8/20 0.39
▸ HSD17B10 Q99714 7/20 0.39
▸ CYP2D6 P10635 12/20 0.39
▸ USP2 O75604 8/20 0.39
▸ HIF1A Q16665 6/20 0.39
▸ MAPK1 P28482 5/20 0.39
▸ TDP1 Q9NUW8 2/20 0.38
▸ KDM4E B2RXH2 2/20 0.38
▸ MEN1 O00255 5/20 0.38
▸ KMT2A Q03164 5/20 0.38
▸ ALOX15 P16050 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30467624 1.00 NPC1 (0.41) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL30467663 0.94 NPC1 (0.44) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL24252834 0.94 NPC1 (0.44) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL30467560 0.93 CYP1A2 (0.40) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL24252823 0.93 CYP1A2 (0.40) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL30467561 0.93 CYP1A2 (0.40) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL29015643 0.91 CYP1A2 (0.41) CYP1A2CYP3A4CYP2C19TSHRALDH1A1
SCHEMBL24252855 0.88 NPC1 (0.38) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL30467639 0.88 NPC1 (0.38) NPC1RAB9ACYP1A2CYP3A4CYP2C19
SCHEMBL24252785 0.87 CYP1A2 (0.42) NPC1RAB9ACYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
EP-4185592-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF Annexon, Inc. (US) 2023-05-31 — — EP disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 NPC1 460/4885RAB9A 2013/4885CYP1A2 2977/4885
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 NPC1 460/4885RAB9A 2013/4885CYP1A2 2977/4885
US-11814404-B2 Inhibitors of complement factors and uses thereof CFB, CFH, C9 NPC1 460/4885RAB9A 2013/4885CYP1A2 2977/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.