Sugi Predict

Sugi Predict / Compounds / SCHEMBL24252363

SCHEMBL24252363

SCHEMBL24252363

COc1ccc(CNc2nnc(C)c3cc(-c4ccc(C(F)(F)CO[Si](C)(C)C(C)(C)C)c(Cl)c4)ccc23)c(OC)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 20/20 0.41
▸ CYP3A4 P08684 20/20 0.41
▸ CYP2C19 P33261 19/20 0.41
▸ CYP2D6 P10635 16/20 0.41
▸ ALDH1A1 P00352 14/20 0.41
▸ TSHR P16473 13/20 0.41
▸ CLK4 Q9HAZ1 12/20 0.41
▸ HSD17B10 Q99714 11/20 0.41
▸ CYP2C9 P11712 11/20 0.41
▸ USP2 O75604 10/20 0.41
▸ MAPK1 P28482 8/20 0.41
▸ MEN1 O00255 4/20 0.41
▸ KMT2A Q03164 4/20 0.41
▸ ALOX15 P16050 4/20 0.41
▸ LMNA P02545 11/20 0.40
▸ HIF1A Q16665 6/20 0.40
▸ TDP1 Q9NUW8 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.38
▸ CASP1 P29466 1/20 0.36
▸ CASP7 P55210 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30467632 1.00 CYP1A2 (0.41) CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1
SCHEMBL24252891 0.87 CYP1A2 (0.46) CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1
SCHEMBL24252433 0.81 CYP1A2 (0.44) CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1
SCHEMBL24252854 0.80 CYP1A2 (0.46) CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1
SCHEMBL30453283 0.80 CYP1A2 (0.46) CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1
SCHEMBL24252890 0.79 CYP1A2 (0.45) CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1
SCHEMBL30451543 0.79 CYP1A2 (0.48) CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1
SCHEMBL24252395 0.79 CYP1A2 (0.48) CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1
SCHEMBL24252382 0.79 CYP1A2 (0.44) CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1
SCHEMBL24252338 0.78 CYP1A2 (0.48) CYP1A2CYP3A4CYP2C19CYP2D6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
EP-4185592-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF Annexon, Inc. (US) 2023-05-31 — — EP disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 CYP1A2 2977/4885CYP3A4 2694/4885CYP2C19 1687/4885
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 CYP1A2 2977/4885CYP3A4 2694/4885CYP2C19 1687/4885
US-11814404-B2 Inhibitors of complement factors and uses thereof CFB, CFH, C9 CYP1A2 2977/4885CYP3A4 2694/4885CYP2C19 1687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.