Sugi Predict

Sugi Predict / Compounds / SCHEMBL24252422

SCHEMBL24252422

SCHEMBL24252422

COc1ccc(CNc2nnc(C)c3cc(-c4cc(P(C)(C)=O)cc(Cl)c4F)ccc23)c(OC)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 19/20 0.42
▸ CYP3A4 P08684 19/20 0.42
▸ CYP2C19 P33261 17/20 0.42
▸ ALDH1A1 P00352 15/20 0.42
▸ CYP2C9 P11712 14/20 0.42
▸ TSHR P16473 13/20 0.42
▸ HSD17B10 Q99714 13/20 0.42
▸ LMNA P02545 11/20 0.42
▸ CLK4 Q9HAZ1 10/20 0.42
▸ CYP2D6 P10635 15/20 0.41
▸ USP2 O75604 9/20 0.41
▸ KDM4E B2RXH2 3/20 0.41
▸ HPGD P15428 2/20 0.41
▸ HIF1A Q16665 7/20 0.40
▸ MAPT P10636 3/20 0.40
▸ TDP1 Q9NUW8 2/20 0.40
▸ SMN1; SMN2 Q16637 2/20 0.40
▸ MAPK1 P28482 5/20 0.40
▸ MEN1 O00255 6/20 0.39
▸ KMT2A Q03164 6/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30452021 1.00 CYP1A2 (0.42) CYP1A2CYP3A4CYP2C19ALDH1A1CYP2C9
SCHEMBL30451241 0.85 CYP1A2 (0.44) CYP1A2CYP3A4CYP2C19ALDH1A1CYP2C9
SCHEMBL24252833 0.85 CYP1A2 (0.44) CYP1A2CYP3A4CYP2C19ALDH1A1CYP2C9
SCHEMBL30451906 0.83 CYP1A2 (0.44) CYP1A2CYP3A4CYP2C19ALDH1A1CYP2C9
SCHEMBL24252811 0.83 CYP1A2 (0.44) CYP1A2CYP3A4CYP2C19ALDH1A1CYP2C9
SCHEMBL31753943 0.82 CYP1A2 (0.52) CYP1A2CYP3A4CYP2C19ALDH1A1CYP2C9
SCHEMBL24252328 0.82 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C19ALDH1A1CYP2C9
SCHEMBL24252327 0.81 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C19ALDH1A1CYP2C9
SCHEMBL30451971 0.81 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C19ALDH1A1CYP2C9
SCHEMBL24252768 0.81 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C19ALDH1A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
CN-116947903-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-10-27 — — CN disclosed
CN-116261564-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-06-13 — — CN disclosed
EP-4185592-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF Annexon, Inc. (US) 2023-05-31 — — EP disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 CYP1A2 2977/4885CYP3A4 2694/4885CYP2C19 1687/4885
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 CYP1A2 2977/4885CYP3A4 2694/4885CYP2C19 1687/4885
US-11814404-B2 Inhibitors of complement factors and uses thereof CFB, CFH, C9 CYP1A2 2977/4885CYP3A4 2694/4885CYP2C19 1687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.