Sugi Predict

Sugi Predict / Compounds / SCHEMBL24252463

SCHEMBL24252463

SCHEMBL24252463

COC(=O)c1ccc(Cl)cc1-c1ccc2c(NCc3ccc(OC)cc3OC)cnnc2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4C Q9H3R0 2/20 0.45
▸ MAPT P10636 2/20 0.41
▸ PLA2G2A P14555 1/20 0.40
▸ CNR1 P21554 1/20 0.40
▸ CNR2 P34972 1/20 0.40
▸ CYP1A2 P05177 11/20 0.40
▸ CYP3A4 P08684 11/20 0.40
▸ CYP2C19 P33261 11/20 0.40
▸ ALDH1A1 P00352 8/20 0.40
▸ CYP2C9 P11712 8/20 0.40
▸ TSHR P16473 8/20 0.40
▸ HSD17B10 Q99714 6/20 0.40
▸ CLK4 Q9HAZ1 4/20 0.40
▸ LMNA P02545 3/20 0.40
▸ CYP2D6 P10635 8/20 0.40
▸ MAPK1 P28482 3/20 0.40
▸ HIF1A Q16665 3/20 0.39
▸ KDM4E B2RXH2 3/20 0.39
▸ USP2 O75604 3/20 0.39
▸ HPGD P15428 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30451581 1.00 KDM4C (0.45) KDM4CMAPTPLA2G2ACNR1CNR2
SCHEMBL24252924 0.93 KDM4C (0.52) KDM4CMAPTCNR1CNR2CYP1A2
SCHEMBL30452330 0.93 KDM4C (0.52) KDM4CMAPTCNR1CNR2CYP1A2
SCHEMBL24252984 0.90 KDM4C (0.43) KDM4CMAPTCNR1CNR2CYP1A2
SCHEMBL30451317 0.89 CYP1A2 (0.46) KDM4CMAPTCNR1CNR2CYP1A2
SCHEMBL24252808 0.89 CYP1A2 (0.46) KDM4CMAPTCNR1CNR2CYP1A2
SCHEMBL30467637 0.88 KDM4C (0.41) KDM4CCNR1CNR2ALDH1A1TSHR
SCHEMBL24252871 0.88 KDM4C (0.41) KDM4CCNR1CNR2ALDH1A1TSHR
Formic Acid SCHEMBL25237585 0.88 KDM4C (0.41) KDM4CMAPTCNR1CNR2CYP1A2
SCHEMBL24253051 0.85 CNR1 (0.40) KDM4CMAPTCNR1CNR2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
CN-116947903-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-10-27 — — CN disclosed
CN-116261564-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-06-13 — — CN disclosed
EP-4185592-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF Annexon, Inc. (US) 2023-05-31 — — EP disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 KDM4C 4542/4885MAPT 1152/4885PLA2G2A 343/4885
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 KDM4C 4542/4885MAPT 1152/4885PLA2G2A 343/4885
US-11814404-B2 Inhibitors of complement factors and uses thereof CFB, CFH, C9 KDM4C 4542/4885MAPT 1152/4885PLA2G2A 343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.