Sugi Predict

Sugi Predict / Compounds / SCHEMBL24252856

SCHEMBL24252856

SCHEMBL24252856

COCCOCCOc1ccc(Cl)cc1-c1ccc2c(NCc3ccc(OC)cc3OC)cnnc2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FLT1 P17948 2/20 0.45
▸ KDR P35968 2/20 0.45
▸ FGFR1 P11362 1/20 0.45
▸ CYP1A2 P05177 13/20 0.40
▸ CYP3A4 P08684 13/20 0.40
▸ CYP2C19 P33261 12/20 0.40
▸ TSHR P16473 10/20 0.40
▸ CYP2C9 P11712 9/20 0.40
▸ ALDH1A1 P00352 9/20 0.40
▸ CLK4 Q9HAZ1 9/20 0.40
▸ HSD17B10 Q99714 7/20 0.40
▸ LMNA P02545 7/20 0.40
▸ CNR1 P21554 1/20 0.39
▸ CNR2 P34972 1/20 0.39
▸ CYP2D6 P10635 11/20 0.39
▸ HIF1A Q16665 4/20 0.39
▸ MAPT P10636 2/20 0.39
▸ TDP1 Q9NUW8 2/20 0.38
▸ GAA P10253 2/20 0.38
▸ MAPK1 P28482 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25248287 1.00 FLT1 (0.45) FLT1KDRFGFR1CYP1A2CYP3A4
SCHEMBL30467782 1.00 FLT1 (0.45) FLT1KDRFGFR1CYP1A2CYP3A4
SCHEMBL30451317 0.90 CYP1A2 (0.46) CYP1A2CYP3A4CYP2C19TSHRCYP2C9
SCHEMBL24252808 0.90 CYP1A2 (0.46) CYP1A2CYP3A4CYP2C19TSHRCYP2C9
SCHEMBL25241818 0.90 GCGR (0.39) FLT1KDRFGFR1CYP1A2CYP3A4
SCHEMBL25212281 0.90 GCGR (0.39) FLT1KDRFGFR1CYP1A2CYP3A4
SCHEMBL30451677 0.88 CYP1A2 (0.41) FLT1KDRFGFR1CYP1A2CYP3A4
SCHEMBL24252454 0.88 CYP1A2 (0.41) FLT1KDRFGFR1CYP1A2CYP3A4
SCHEMBL30467703 0.87 CNR2 (0.37) FLT1KDRFGFR1CYP1A2CYP3A4
SCHEMBL30467572 0.87 CNR2 (0.37) FLT1KDRFGFR1CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
CN-116947903-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-10-27 — — CN disclosed
CN-116261564-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-06-13 — — CN disclosed
EP-4185592-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF Annexon, Inc. (US) 2023-05-31 — — EP disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 FLT1 3910/4885KDR 3397/4885FGFR1 4034/4885
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 FLT1 3910/4885KDR 3397/4885FGFR1 4034/4885
US-11814404-B2 Inhibitors of complement factors and uses thereof CFB, CFH, C9 FLT1 3910/4885KDR 3397/4885FGFR1 4034/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.