SCHEMBL24252898

SCHEMBL24252898

Oc1cnnc2cc(Br)c(F)cc12

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
STING1 Q86WV6 1/20 0.31
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL29015475 0.98 STING1 (0.30) STING1ESR1ESR2
SCHEMBL21494416 0.93 STING1 (0.31) STING1ESR1ESR2
SCHEMBL30451438 0.83
SCHEMBL24252421 0.83
SCHEMBL24252971 0.79 KDM1A (0.33)
SCHEMBL30467842 0.79 KDM1A (0.33)
SCHEMBL16646964 0.79 AR (0.32)
SCHEMBL25220803 0.75 IDO1 (0.34)
SCHEMBL12861090 0.74 SRC (0.32)
SCHEMBL15010142 0.71 KDM4E (0.35) ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 US disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 STING1 2862/4885ESR1 4849/4885ESR2 4114/4885
US-11814404-B2 Inhibitors of complement factors and uses thereof CFB, CFH, C9 STING1 2862/4885ESR1 4849/4885ESR2 4114/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.