Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | PLK1 | P53350 | 4/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | FECH | P22830 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122901 | 0.90 | ABCG2 (0.43) | HDAC1HDAC6PLK1HDAC4HDAC8 | |
| SCHEMBL2417641 | 0.87 | ABCG2 (0.44) | HDAC1HDAC6PLK1HDAC4HDAC8 | |
| SCHEMBL1123357 | 0.87 | ABCG2 (0.44) | HDAC1HDAC6PLK1HDAC4HDAC8 | |
| SCHEMBL1122869 | 0.85 | HDAC4 (0.48) | HDAC1HDAC6PLK1HDAC4HDAC8 | |
| SCHEMBL1122957 | 0.84 | ABCG2 (0.42) | HDAC1HDAC6PLK1HDAC4HDAC8 | |
| SCHEMBL1123049 | 0.84 | HDAC4 (0.48) | HDAC1HDAC6PLK1HDAC4HDAC8 | |
| SCHEMBL1123035 | 0.84 | PLK1 (0.42) | HDAC1HDAC6PLK1HDAC4HDAC8 | |
| SCHEMBL1122898 | 0.84 | GAA (0.49) | HDAC1HDAC6HDAC8ABCG2TP53 | |
| SCHEMBL1122999 | 0.84 | TP53 (0.44) | HDAC1HDAC6PLK1HDAC4HDAC8 | |
| SCHEMBL1123010 | 0.83 | PLK1 (0.48) | HDAC1HDAC6PLK1HDAC4HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487428-B1 | AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2011-09-21 | — | — | EP | disclosed |