Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | CA4 | P22748 | 1/20 | 0.62 |
| ▸ | PTGER3 | P43115 | 7/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 7/20 | 0.55 |
| ▸ | PTGER4 | P35408 | 6/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | TNKS | O95271 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78555 | 1.00 | CA1 (0.62) | CA1CA2NFKB1CA4PTGER3 | |
| SCHEMBL78556 | 1.00 | CA1 (0.62) | CA1CA2NFKB1CA4PTGER3 | |
| SCHEMBL29386378 | 1.00 | CA1 (0.62) | CA1CA2NFKB1CA4PTGER3 | |
| Hydrochloric Acid SCHEMBL9445634 | 0.98 | CA1 (0.60) | CA1CA2NFKB1CA4PTGER3 | |
| Ammonia Solution, Strong SCHEMBL6324720 | 0.98 | CA1 (0.60) | CA1CA2NFKB1CA4PTGER3 | |
| Hydrochloric Acid SCHEMBL16239458 | 0.98 | CA1 (0.60) | CA1CA2NFKB1CA4PTGER3 | |
| Ammonia Solution, Strong SCHEMBL6324726 | 0.98 | CA1 (0.60) | CA1CA2NFKB1CA4PTGER3 | |
| SCHEMBL5666241 | 0.98 | CA1 (0.60) | CA1CA2NFKB1CA4PTGER3 | |
| SCHEMBL5666236 | 0.98 | CA1 (0.60) | CA1CA2NFKB1CA4PTGER3 | |
| Tert-Butylamine SCHEMBL1879651 | 0.91 | CA1 (0.53) | CA1CA2NFKB1CA4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101598-B1 | TOBACCO PRODUCT, PREPARATION AND USES THEREOF | BRITISH AMERICAN TOBACCO CO (GB) | 2011-09-28 | — | — | EP | claimed |
| EP-2780008-B1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | MERIAL INC (US) | 2017-07-05 | — | — | EP | disclosed |
| US-9173404-B2 | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof | MERIAL, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-9173404-B2 | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof | MERIAL, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-9125407-B2 | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof | MERIAL, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| US-9125407-B2 | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof | MERIAL, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| US-20150011601-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | MERIAL LIMITED (US) | 2015-01-08 | — | — | US | disclosed |
| US-20150011601-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | MERIAL LIMITED (US) | 2015-01-08 | — | — | US | disclosed |
| US-20140303220-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | MERIAL LIMITED (US) | 2014-10-09 | — | — | US | disclosed |
| US-20140303220-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | MERIAL LIMITED (US) | 2014-10-09 | — | — | US | disclosed |
| WO-2013074892-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | MERIAL LIMITED (US) | 2013-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303220-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | TYR, AADAC, PIR | CA1 3350/4885CA2 1742/4885NFKB1 3990/4885 |
| US-20150011601-A1 | COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF | TYR, AADAC, PIR | CA1 3350/4885CA2 1742/4885NFKB1 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.