Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 9/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | ROS1 | P08922 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | STK17B | O94768 | 3/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24255246 | 0.92 | TNK2 (0.51) | TNK2NTRK1JAK2CHEK1ABL1 | |
| SCHEMBL24255516 | 0.91 | TNK2 (0.52) | TNK2NTRK1JAK2CHEK1ABL1 | |
| SCHEMBL24255313 | 0.86 | TNK2 (0.57) | TNK2NTRK1JAK2CHEK1ABL1 | |
| SCHEMBL24255318 | 0.85 | MAPK9 (0.52) | TNK2NTRK1JAK2CHEK1ABL1 | |
| SCHEMBL24255328 | 0.84 | TNK2 (0.55) | TNK2NTRK1JAK2CHEK1ABL1 | |
| SCHEMBL24255317 | 0.80 | TNK2 (0.60) | TNK2NTRK1JAK2CHEK1ABL1 | |
| SCHEMBL24255243 | 0.79 | MAPK9 (0.55) | TNK2NTRK1JAK2CHEK1ABL1 | |
| SCHEMBL26270099 | 0.78 | TNK2 (0.61) | TNK2NTRK1JAK2CHEK1ABL1 | |
| SCHEMBL24255244 | 0.78 | TNK2 (0.58) | TNK2NTRK1JAK2CHEK1ABL1 | |
| SCHEMBL26270103 | 0.77 | TNK2 (0.58) | TNK2NTRK1JAK2CHEK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036312-A2 | INHIBITORS OF ACK1/TNK1 TYROSINE KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |