Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 17/20 | 0.71 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | SRC | P12931 | 2/20 | 0.65 |
| ▸ | ROS1 | P08922 | 2/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.64 |
| ▸ | TYK2 | P29597 | 1/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26270588 | 0.93 | TNK2 (0.82) | TNK2ALKJAK2SRCROS1 | |
| SCHEMBL24255341 | 0.93 | TNK2 (0.82) | TNK2ALKJAK2SRCROS1 | |
| SCHEMBL24255483 | 0.87 | TNK2 (0.70) | TNK2ALKJAK2SRCROS1 | |
| SCHEMBL24255515 | 0.85 | TNK2 (0.79) | TNK2ALKJAK2SRCROS1 | |
| SCHEMBL24255476 | 0.85 | TNK2 (0.79) | TNK2ALKJAK2SRCROS1 | |
| SCHEMBL24255512 | 0.83 | TNK2 (0.69) | TNK2ALKJAK2SRCROS1 | |
| SCHEMBL24255504 | 0.80 | TNK2 (0.82) | TNK2ALKJAK2SRCROS1 | |
| SCHEMBL26361443 | 0.80 | TNK2 (0.61) | TNK2ALKJAK2SRCROS1 | |
| SCHEMBL24255519 | 0.79 | TNK2 (0.74) | TNK2ALKJAK2SRCROS1 | |
| SCHEMBL24255343 | 0.79 | TNK2 (0.76) | TNK2ALKJAK2SRCROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036312-A2 | INHIBITORS OF ACK1/TNK1 TYROSINE KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |