Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 5/20 | 0.48 |
| ▸ | RAD52 | P43351 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | IDE | P14735 | 1/20 | 0.48 |
| ▸ | UBE2N | P61088 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24256695 | 0.86 | KDM4E (0.53) | KDM4EHTTRAD52MAPK1MAPT | |
| SCHEMBL24256614 | 0.85 | HTT (0.55) | KDM4EHTTRAD52MAPK1MAPT | |
| SCHEMBL24256699 | 0.74 | KDM4E (0.49) | KDM4EHTTRAD52MAPK1MAPT | |
| SCHEMBL24256703 | 0.74 | POLB (0.47) | KDM4EHTTRAD52MAPK1MAPT | |
| SCHEMBL24256613 | 0.73 | RAD52 (0.47) | KDM4EHTTRAD52MAPK1MAPT | |
| SCHEMBL24256352 | 0.72 | POLB (0.51) | KDM4EHTTRAD52MAPK1MAPT | |
| SCHEMBL24256356 | 0.71 | NPC1 (0.48) | KDM4EHTTRAD52MAPK1MAPT | |
| SCHEMBL24256846 | 0.71 | KMT2A (0.49) | KDM4EHTTRAD52MAPK1MAPT | |
| SCHEMBL24256693 | 0.70 | KDM4E (0.46) | KDM4EHTTRAD52MAPK1MAPT | |
| SCHEMBL24256706 | 0.70 | NPC1 (0.49) | KDM4EHTTRAD52MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035806-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |