Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.40 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24256362 | 0.86 | HPGD (0.52) | MTORLMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL24256612 | 0.86 | MTOR (0.60) | MTORLMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL24256908 | 0.86 | KDM4E (0.51) | LMNAHPGDSMN1; SMN2MAPTHTT | |
| SCHEMBL24256883 | 0.86 | KDM4E (0.51) | LMNAHPGDSMN1; SMN2MAPTHTT | |
| SCHEMBL24256707 | 0.85 | MTOR (0.58) | MTORLMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL24256709 | 0.85 | MTOR (0.61) | MTORLMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL24256858 | 0.76 | MTOR (0.63) | MTORLMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL24256358 | 0.76 | KDM4E (0.52) | MTORLMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL26780707 | 0.75 | KDM4E (0.51) | MTORLMNAHPGDMAPTHTT | |
| SCHEMBL24256669 | 0.75 | MTOR (0.48) | MTORLMNAHPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035806-A1 | FUSED TRICYCLIC PYRIMIDINE-THIENO-PYRIDINE SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |