Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 18/20 | 0.68 |
| ▸ | VEGFA | P15692 | 3/20 | 0.53 |
| ▸ | FLT1 | P17948 | 3/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.53 |
| ▸ | TET3 | O43151 | 1/20 | 0.50 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.50 |
| ▸ | ASPH | Q12797 | 1/20 | 0.50 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.50 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.50 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.50 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.50 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24257633 | 0.89 | EGLN1 (0.65) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL24257542 | 0.89 | EGLN1 (0.67) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL24257497 | 0.87 | EGLN1 (0.57) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL24257510 | 0.86 | EGLN1 (0.61) | EGLN1BBOX1ASPHKDM8 | |
| SCHEMBL30546862 | 0.85 | EGLN3 (0.55) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL24257682 | 0.85 | EGLN3 (0.55) | EGLN1VEGFAFLT1EGLN3TET3 | |
| SCHEMBL24257567 | 0.84 | EGLN1 (0.65) | EGLN1VEGFAFLT1EGLN3HIF1AN | |
| SCHEMBL24257518 | 0.82 | EGLN1 (0.50) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL24257601 | 0.82 | EGLN1 (0.56) | EGLN1VEGFAFLT1EGLN3 | |
| SCHEMBL30546834 | 0.82 | EGLN1 (0.56) | EGLN1VEGFAFLT1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036188-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2022-02-17 | — | — | WO | disclosed |