Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.66 |
| ▸ | INSR | P06213 | 6/20 | 0.66 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | IGF1R | P08069 | 2/20 | 0.55 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24258115 | 0.93 | ALK (0.66) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL26361771 | 0.93 | ALK (0.66) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL26361415 | 0.93 | ALK (0.66) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL24258110 | 0.86 | ALK (0.67) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL24258141 | 0.86 | ALK (0.67) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL24255315 | 0.84 | ALK (0.67) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL26361392 | 0.82 | ALK (0.64) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL24255323 | 0.82 | ALK (0.57) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL24258139 | 0.82 | ALK (0.63) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL26361813 | 0.82 | ALK (0.63) | ALKINSRLRRK2EGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022036310-A2 | INHIBITORS OF ACK1/TNK1 TYROSINE KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |