Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22134431 | 0.86 | GRM4 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20287581 | 0.84 | GAA (0.42) | HSD17B10GAARAB9ASMN1; SMN2PSEN1 | |
| SCHEMBL20286452 | 0.84 | GAA (0.42) | HSD17B10GAARAB9ASMN1; SMN2PSEN1 | |
| SCHEMBL26212331 | 0.81 | GAA (0.51) | HSD17B10GAARAB9ASMN1; SMN2MMP2 | |
| SCHEMBL25785457 | 0.76 | PSEN1 (0.41) | HSD17B10GAASMN1; SMN2PSEN1PSEN2 | |
| SCHEMBL12384303 | 0.76 | HSD17B10 (0.62) | HSD17B10GAARAB9ASMN1; SMN2MMP2 | |
| SCHEMBL6385930 | 0.73 | HSD17B10 (0.62) | HSD17B10GAARAB9ASMN1; SMN2MMP2 | |
| SCHEMBL7750667 | 0.72 | HSD17B10 (0.66) | HSD17B10GAARAB9ASMN1; SMN2MMP2 | |
| SCHEMBL15592763 | 0.72 | ACE (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19091400 | 0.72 | ACE (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3432934-B1 | PRODRUGS OF CYTOTOXIC AGENTS WITH ENZYMATICALLY CLEAVABLE GROUPS | Bayer Pharma AG (DE) | 2022-02-23 | — | — | EP | disclosed |