⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24276781 | 0.82 | — | — | |
| SCHEMBL28952763 | 0.79 | GLP1R (0.36) | — | |
| SCHEMBL23748578 | 0.79 | GLP1R (0.36) | — | |
| Hydrochloric Acid SCHEMBL28952252 | 0.78 | GLP1R (0.35) | — | |
| Hydrochloric Acid SCHEMBL28952250 | 0.78 | GLP1R (0.35) | — | |
| SCHEMBL24276966 | 0.77 | GLP1R (0.32) | — | |
| SCHEMBL24277080 | 0.76 | GLP1R (0.39) | — | |
| SCHEMBL31323141 | 0.74 | GLP1R (0.36) | — | |
| SCHEMBL31323151 | 0.74 | GLP1R (0.36) | — | |
| Hydrochloric Acid SCHEMBL31323082 | 0.73 | GLP1R (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12595264-B2 | Heterocyclic GLP-1 agonists | GASHERBRUM BIO, INC. (US) | 2026-04-07 | — | — | US | disclosed |
| US-20230331732-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2023-10-19 | — | — | US | disclosed |
| US-20230331732-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2023-10-19 | — | — | US | disclosed |
| EP-4211139-A1 | HETEROCYCLIC GLP-1 AGONISTS | Gasherbrum Bio, Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| CN-116368140-A | Heterocyclic GLP-1 agonists | 加舒布鲁姆生物公司 | 2023-06-30 | — | — | CN | disclosed |
| WO-2022052958-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. (US) | 2022-03-17 | — | — | WO | disclosed |
| WO-2022052958-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. (US) | 2022-03-17 | — | — | WO | disclosed |