SCHEMBL24281141

SCHEMBL24281141

O=C(Nc1cc(NC(=O)C(F)(F)F)c(F)cc1F)c1cc(NC(=O)C2[C@H](c3cc(Cl)c(Cl)c(Cl)c3)C2(Cl)Cl)cc(F)c1Cl

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.36
KMT2A Q03164 5/20 0.36
LMNA P02545 4/20 0.36
ALDH1A1 P00352 1/20 0.33
RECQL P46063 1/20 0.33
MAPT P10636 2/20 0.32
MAPK1 P28482 1/20 0.32
TRPV1 Q8NER1 1/20 0.31
ATF1 P18846 1/20 0.31
NFKB1 P19838 1/20 0.31
HTT P42858 2/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20050704 1.00 MEN1 (0.36) MEN1KMT2ALMNAALDH1A1RECQL
SCHEMBL24281575 0.94 MEN1 (0.36) MEN1KMT2ALMNAALDH1A1RECQL
SCHEMBL20051006 0.94 MEN1 (0.36) MEN1KMT2ALMNAALDH1A1RECQL
SCHEMBL20050706 0.93 MEN1 (0.39) MEN1KMT2ALMNAALDH1A1RECQL
SCHEMBL24281951 0.92 MEN1 (0.35) MEN1KMT2ALMNAALDH1A1RECQL
SCHEMBL20051608 0.92 MEN1 (0.35) MEN1KMT2ALMNAALDH1A1RECQL
SCHEMBL24281960 0.92 MEN1 (0.37) MEN1KMT2ALMNAALDH1A1RECQL
SCHEMBL20901092 0.92 MEN1 (0.39) MEN1KMT2ALMNAALDH1A1RECQL
SCHEMBL20051141 0.92 MEN1 (0.37) MEN1KMT2ALMNAALDH1A1RECQL
SCHEMBL20051183 0.90 KMT2A (0.42) MEN1KMT2ALMNAALDH1A1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3971166-A1 MOLECULES HAVING PESTICIDAL UTILITY, AND COMPOSITIONS, AND PROCESSES, RELATED THERETO Corteva Agriscience LLC (US) 2022-03-23 EP disclosed