Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.66 |
| ▸ | KIT | P10721 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | PRKACA | P17612 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | MARK3 | P27448 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | AKT2 | P31751 | 1/20 | 0.56 |
| ▸ | BLK | P51451 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24288644 | 0.86 | KDR (0.52) | KDRKITFLT3CSF1RFGFR1 | |
| SCHEMBL24290092 | 0.83 | KDR (0.53) | KDRKITFLT3LCKCSF1R | |
| SCHEMBL28871219 | 0.82 | KDR (0.66) | KDRKITFLT3LCKCSF1R | |
| SCHEMBL29968063 | 0.82 | KDR (0.66) | KDRKITFLT3LCKCSF1R | |
| SCHEMBL17034042 | 0.81 | KDR (1.00) | KDR | |
| SCHEMBL29549949 | 0.81 | KDR (1.00) | KDR | |
| SCHEMBL6013181 | 0.79 | KDR (0.90) | KDRKITFLT3LCKCSF1R | |
| SCHEMBL419502 | 0.77 | KDR (0.62) | KDRKITFLT3LCKCSF1R | |
| SCHEMBL29968270 | 0.77 | KDR (0.62) | KDRKITFLT3LCKCSF1R | |
| SCHEMBL17034073 | 0.77 | KDR (1.00) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3112351-B1 | NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-03-30 | — | — | EP | disclosed |