Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 4/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24290032 | 0.82 | CYP2A6 (0.41) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL31111498 | 0.79 | KDR (0.41) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL29590652 | 0.79 | JAK2 (0.50) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL24290035 | 0.79 | JAK2 (0.39) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL29077808 | 0.79 | KDR (0.39) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL24290034 | 0.79 | JAK2 (0.50) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL24292037 | 0.79 | JAK2 (0.50) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL27091257 | 0.79 | JAK2 (0.39) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL28545279 | 0.78 | MCL1 (0.46) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL26522082 | 0.77 | CLK2 (0.50) | JAK2JAK1TYK2JAK3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022073469-A1 | COMPOUNDS AND METHODS OF TREATING CANCERS | CULLGEN (SHANGHAI) , INC. (CN) | 2022-04-14 | — | — | WO | disclosed |