Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.67 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.55 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22566226 | 1.00 | CRBN (0.67) | CRBNIKZF2IKZF1CSNK1A1 | |
| SCHEMBL24294345 | 1.00 | CRBN (0.67) | CRBNIKZF2IKZF1CSNK1A1 | |
| SCHEMBL30270897 | 0.95 | CRBN (0.67) | CRBNIKZF2IKZF1CSNK1A1 | |
| SCHEMBL24921704 | 0.95 | CRBN (0.67) | CRBNIKZF2IKZF1CSNK1A1 | |
| SCHEMBL24294480 | 0.95 | CRBN (0.67) | CRBNIKZF2IKZF1CSNK1A1 | |
| SCHEMBL25650423 | 0.95 | CRBN (0.67) | CRBNIKZF2IKZF1CSNK1A1 | |
| SCHEMBL22557008 | 0.90 | CRBN (0.69) | CRBNIKZF2IKZF1CSNK1A1 | |
| SCHEMBL29876913 | 0.90 | CRBN (0.69) | CRBNIKZF2IKZF1CSNK1A1 | |
| SCHEMBL25011588 | 0.90 | CRBN (0.73) | CRBNIKZF2CSNK1A1 | |
| SCHEMBL23565589 | 0.86 | CRBN (0.68) | CRBNIKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |
| EP-3971176-A1 | AROMATIC AMINE AR AND BET TARGETING PROTEIN DEGRADATION CHIMERA COMPOUND AND USE | Hinova Pharmaceuticals Inc. (CN) | 2022-03-23 | — | — | EP | disclosed |
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |