Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 9/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | FAP | Q12884 | 6/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14480015 | 1.00 | DPP4 (0.40) | DPP4HSD17B10LMNACYP2C19FAP | |
| SCHEMBL1920132 | 1.00 | DPP4 (0.40) | DPP4HSD17B10LMNACYP2C19FAP | |
| SCHEMBL5002190 | 1.00 | DPP4 (0.40) | DPP4HSD17B10LMNACYP2C19FAP | |
| SCHEMBL2330612 | 0.95 | HPGD (0.38) | DPP4HSD17B10LMNACYP2C19FAP | |
| SCHEMBL16600622 | 0.89 | DPP4 (0.34) | DPP4HSD17B10LMNACYP2C19RIPK1 | |
| SCHEMBL322779 | 0.89 | DPP4 (0.34) | DPP4HSD17B10LMNACYP2C19RIPK1 | |
| SCHEMBL4523902 | 0.89 | DPP4 (0.34) | DPP4HSD17B10LMNACYP2C19RIPK1 | |
| SCHEMBL322778 | 0.89 | DPP4 (0.34) | DPP4HSD17B10LMNACYP2C19RIPK1 | |
| Hydrochloric Acid SCHEMBL7517295 | 0.87 | DPP4 (0.33) | DPP4LMNARIPK1 | |
| SCHEMBL29392820 | 0.85 | DPP4 (0.40) | DPP4HSD17B10LMNACYP2C19FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2762476-A1 | 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE | Taiho Pharmaceutical Co., Ltd. (JP) | 2014-08-06 | — | — | EP | disclosed |
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |
| EP-2366698-A1 | Derivatives of urea and related diamines, methods for their manufacture, and uses therefor | Galapagos SAS (FR) | 2011-09-21 | — | — | EP | disclosed |