Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.65 |
| ▸ | FLT1 | P17948 | 2/20 | 0.53 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.52 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11966275 | 0.90 | KDR (0.81) | KDRKCNH2FLT1FLT4RET | |
| SCHEMBL2430884 | 0.90 | KDR (1.00) | KDRKCNH2FLT1FLT4RET | |
| SCHEMBL2509786 | 0.90 | KDR (1.00) | KDRKCNH2FLT1FLT4RET | |
| SCHEMBL11966518 | 0.89 | KDR (0.79) | KDRKCNH2FLT1FLT4RET | |
| SCHEMBL2503460 | 0.89 | KDR (0.86) | KDRKCNH2FLT1FLT4RET | |
| SCHEMBL11966519 | 0.89 | KDR (0.79) | KDRKCNH2FLT1FLT4RET | |
| SCHEMBL2503817 | 0.89 | KDR (0.79) | KDRKCNH2FLT1FLT4RET | |
| SCHEMBL11966520 | 0.89 | KDR (0.79) | KDRKCNH2FLT1FLT4RET | |
| SCHEMBL2508055 | 0.88 | KDR (0.71) | KDRKCNH2FLT1FLT4RET | |
| SCHEMBL2503400 | 0.87 | KDR (0.83) | KDRKCNH2FLT1FLT4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |