Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.69 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.69 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.69 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.69 |
| ▸ | RICTOR | Q6R327 | 6/20 | 0.69 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.69 |
| ▸ | MAPKAP1 | Q9BPZ7 | 6/20 | 0.69 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.69 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.69 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.59 |
| ▸ | PRKDC | P78527 | 3/20 | 0.59 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | STK16 | O75716 | 1/20 | 0.58 |
| ▸ | STK10 | O94804 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sapanisertib SCHEMBL29351459 | 0.82 | MTOR (1.00) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| Sapanisertib SCHEMBL7902875 | 0.82 | MTOR (1.00) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL16546279 | 0.81 | MTOR (0.84) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL15497301 | 0.80 | MTOR (0.79) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL7895680 | 0.80 | MTOR (0.79) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL15497291 | 0.80 | MTOR (0.79) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL7903995 | 0.79 | MTOR (0.71) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| Sapanisertib SCHEMBL7895668 | 0.79 | MTOR (0.77) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL20112902 | 0.79 | MTOR (0.74) | MTORPIK3CAPIK3CDPIK3CGPIK3CB | |
| SCHEMBL30880103 | 0.78 | MTOR (0.75) | MTORPIK3CAPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3153023-B1 | BENZOXAZOLE KINASE INHIBITORS AND METHODS OF USE | TAKEDA PHARMACEUTICALS CO (JP) | 2022-03-16 | — | — | EP | disclosed |