Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 19/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.45 |
| ▸ | MET | P08581 | 6/20 | 0.45 |
| ▸ | FLT3 | P36888 | 5/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316443 | 0.79 | CSF1R (0.59) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL24316799 | 0.72 | CSF1R (0.48) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL23900575 | 0.69 | CSF1R (0.49) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL16561327 | 0.69 | CCR1 (0.58) | CSF1RPDGFRAPDGFRBFLT3KDR | |
| SCHEMBL29539281 | 0.68 | CSF1R (0.46) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL24317050 | 0.68 | CSF1R (0.46) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL24317049 | 0.68 | CSF1R (0.46) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL16061920 | 0.68 | CSF1R (0.56) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL23900573 | 0.68 | CSF1R (0.48) | CSF1RPDGFRAPDGFRBMETFLT3 | |
| SCHEMBL16060927 | 0.67 | CSF1R (0.56) | CSF1RPDGFRAPDGFRBMETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057895-A1 | HETEROAROMATIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-03-24 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |