Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 13/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 13/20 | 0.47 |
| ▸ | TOP2A | P11388 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27012683 | 1.00 | DDB1 (0.47) | DDB1CRBNTOP2ATDP1ALDH1A1 | |
| SCHEMBL24317477 | 0.91 | CRBN (0.56) | DDB1CRBNTDP1ALDH1A1CHRM2 | |
| SCHEMBL27012996 | 0.91 | TOP2A (0.43) | DDB1CRBNTOP2ATDP1BCL2L11 | |
| SCHEMBL27012686 | 0.86 | CRBN (0.47) | DDB1CRBNTDP1ALDH1A1CHRM2 | |
| SCHEMBL24317578 | 0.86 | DDB1 (0.45) | DDB1CRBNTDP1ALDH1A1CHRM2 | |
| SCHEMBL24317484 | 0.85 | DDB1 (0.50) | DDB1CRBNTDP1ALDH1A1CHRM2 | |
| SCHEMBL29532505 | 0.85 | CRBN (0.52) | DDB1CRBNTDP1ALDH1A1CHRM2 | |
| SCHEMBL24317452 | 0.85 | CRBN (0.52) | DDB1CRBNTDP1ALDH1A1CHRM2 | |
| SCHEMBL24317476 | 0.85 | CRBN (0.49) | DDB1CRBNTDP1ALDH1A1CHRM2 | |
| SCHEMBL24317479 | 0.84 | CRBN (0.50) | DDB1CRBNTDP1ALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |