Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26619764 | 0.88 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3HRH3MAPT | |
| SCHEMBL24317561 | 0.86 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HRH3KCNH2 | |
| SCHEMBL27010171 | 0.83 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HRH3MAPT | |
| SCHEMBL13798741 | 0.76 | SLC6A2 (0.67) | SLC6A2SLC6A4SLC6A3CHRNB4CHRNA3 | |
| SCHEMBL26619758 | 0.75 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3HRH3MAPT | |
| SCHEMBL26619696 | 0.75 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3HRH3KCNH2 | |
| SCHEMBL7533532 | 0.74 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3HRH3MAPT | |
| SCHEMBL7533925 | 0.74 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3HRH3MAPT | |
| SCHEMBL7533530 | 0.74 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3HRH3MAPT | |
| SCHEMBL26632862 | 0.73 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3HRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |