SCHEMBL24318973

SCHEMBL24318973

CNc1ccc(C)c(-c2cc(C#CC(C)(C)O)nc(N3CCOCC3)c2)c1

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 20/20 0.67
BRAF P15056 4/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24318983 0.81 RAF1 (0.66) RAF1BRAF
SCHEMBL24312187 0.81 RAF1 (1.00) RAF1BRAF
SCHEMBL29566618 0.81 RAF1 (1.00) RAF1BRAF
SCHEMBL24765971 0.80 RAF1 (0.85) RAF1BRAF
SCHEMBL24319005 0.79 RAF1 (0.53) RAF1BRAF
SCHEMBL24319041 0.79 RAF1 (0.47) RAF1BRAF
SCHEMBL24765972 0.78 RAF1 (1.00) RAF1BRAF
SCHEMBL24312432 0.78 RAF1 (0.63) RAF1BRAF
SCHEMBL21091648 0.74 RAF1 (0.49) RAF1BRAF
SCHEMBL24318084 0.73 RAF1 (0.68) RAF1BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022081469-A1 INHIBITORS OF RAF KINASES KINNATE BIOPHARMA INC. (US) 2022-04-21 WO disclosed