Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | BCR | P11274 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431020 | 0.98 | ABL1 (0.60) | ABL1BCRAURKAACKR3FLT3 | |
| SCHEMBL2433994 | 0.98 | ABL1 (0.61) | ABL1BCRAURKAACKR3FLT3 | |
| SCHEMBL2439137 | 0.98 | ABL1 (0.61) | ABL1BCRAURKAACKR3FLT3 | |
| SCHEMBL2433100 | 0.93 | ABL1 (0.52) | ABL1BCRAURKAACKR3FLT3 | |
| SCHEMBL2435084 | 0.91 | ABL1 (0.53) | ABL1BCRACKR3KDRHRH3 | |
| SCHEMBL2434312 | 0.90 | ABL1 (0.51) | ABL1BCRAURKAACKR3FLT3 | |
| SCHEMBL2434904 | 0.90 | ABL1 (0.52) | ABL1BCRAURKAACKR3FLT3 | |
| SCHEMBL2432351 | 0.89 | ABL1 (0.48) | ABL1BCRAURKAACKR3FLT3 | |
| SCHEMBL740623 | 0.88 | ABL1 (0.72) | ABL1BCRAURKAACKR3FLT3 | |
| SCHEMBL2432671 | 0.87 | ABL1 (0.51) | ABL1BCRAURKAFLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007380-B1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2011-09-14 | — | — | EP | claimed |