Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | CRHBP | P24387 | 2/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432446 | 1.00 | KDM4E (0.38) | KDM4EHTTATMMAPTTP53 | |
| SCHEMBL3841003 | 0.88 | CYP2E1 (0.35) | KDM4EHTTATMCYP17A1BRD4 | |
| SCHEMBL2429066 | 0.85 | KDM4E (0.39) | KDM4EHTTATMMAPTTP53 | |
| SCHEMBL2429067 | 0.85 | KDM4E (0.39) | KDM4EHTTATMMAPTTP53 | |
| SCHEMBL2433936 | 0.84 | MAPT (0.43) | KDM4EHTTATMMAPTTP53 | |
| SCHEMBL2433933 | 0.84 | MAPT (0.43) | KDM4EHTTATMMAPTTP53 | |
| SCHEMBL2436040 | 0.83 | PTPN1 (0.45) | KDM4EHTTATMMAPTTP53 | |
| SCHEMBL2432217 | 0.83 | KDM4E (0.36) | KDM4EHTTATMMAPTTP53 | |
| SCHEMBL3841046 | 0.83 | KDM4E (0.36) | KDM4EHTTATMMAPTTP53 | |
| SCHEMBL2436043 | 0.83 | PTPN1 (0.45) | KDM4EHTTATMMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086966-B1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-09-14 | — | — | EP | disclosed |