Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 12/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2428776 | 0.97 | AKR1C3 (0.42) | PTGER4CYP1A2CYP2D6AKR1C3AKR1C2 | |
| SCHEMBL2431779 | 0.90 | PTGER4 (0.44) | PTGER4CYP1A2CYP2D6AKR1C3AKR1C2 | |
| SCHEMBL1591410 | 0.89 | PTGER4 (0.44) | PTGER4CYP1A2CYP2D6AKR1C3AKR1C2 | |
| SCHEMBL1590718 | 0.88 | PTGER4 (0.45) | PTGER4CYP1A2CYP2D6AKR1C3AKR1C2 | |
| SCHEMBL1591043 | 0.88 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL2430703 | 0.87 | PTGER4 (0.62) | PTGER4 | |
| SCHEMBL2429354 | 0.87 | PTGER4 (0.62) | PTGER4 | |
| SCHEMBL1590264 | 0.84 | PTGER4 (0.42) | PTGER4CYP1A2CYP2D6AKR1C3AKR1C2 | |
| SCHEMBL1590785 | 0.83 | AKR1C3 (0.37) | PTGER4CYP1A2CYP2D6AKR1C3AKR1C2 | |
| SCHEMBL2299558 | 0.83 | PTGER4 (0.48) | PTGER4CYP1A2CYP2D6AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026270-B2 | Benzo [F] isoindoles as EP4 receptor agonists | GLAXO GROUP LIMITED (GB) | 2011-09-27 | — | — | US | disclosed |