Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9236772 | 0.83 | AKT1 (0.51) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL24326682 | 0.83 | AKT1 (0.51) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL29060346 | 0.82 | AKT1 (0.47) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL27011276 | 0.82 | AKT1 (0.47) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL26869291 | 0.82 | SYK (0.52) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL27019058 | 0.81 | AKT1 (0.47) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL24323548 | 0.80 | SYK (0.50) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL6541506 | 0.80 | AKT1 (0.46) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL24326681 | 0.79 | AKT1 (0.49) | SYKAKT1CTSSCTSLCTSB | |
| SCHEMBL27132402 | 0.79 | AKT1 (0.49) | SYKAKT1CTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076625-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |