Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.40 |
| ▸ | JAK1 | P23458 | 7/20 | 0.40 |
| ▸ | TYK2 | P29597 | 7/20 | 0.40 |
| ▸ | JAK3 | P52333 | 7/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 5/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327328 | 0.88 | JAK2 (0.44) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL24327333 | 0.88 | JAK2 (0.44) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL29601453 | 0.88 | JAK2 (0.44) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL29601470 | 0.85 | JAK2 (0.40) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL24327357 | 0.85 | JAK2 (0.39) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL24327772 | 0.82 | JAK2 (0.38) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL24327398 | 0.82 | JAK2 (0.39) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL24328761 | 0.81 | JAK2 (0.38) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL24327974 | 0.81 | JAK2 (0.41) | JAK2JAK1TYK2JAK3AHR | |
| SCHEMBL28724034 | 0.81 | JAK2 (0.41) | JAK2JAK1TYK2JAK3AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |