⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13537005 | 0.81 | — | — | |
| SCHEMBL8739934 | 0.80 | PARP1 (0.46) | — | |
| SCHEMBL29561513 | 0.78 | — | — | |
| SCHEMBL506617 | 0.78 | — | — | |
| SCHEMBL378869 | 0.76 | — | — | |
| SCHEMBL3671171 | 0.76 | — | — | |
| SCHEMBL14157117 | 0.76 | — | — | |
| SCHEMBL906702 | 0.76 | — | — | |
| SCHEMBL101950 | 0.76 | — | — | |
| SCHEMBL30846305 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8742124-B2 | Amide derivatives bearing a cyclopropylaminoacarbonyl substituent useful as cytokine inhibitors | ASTRAZENECA AB (SE) | 2014-06-03 | — | — | US | disclosed |
| US-20130035346-A1 | AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2013-02-07 | — | — | US | disclosed |
| US-20120004243-A1 | AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2012-01-05 | — | — | US | disclosed |
| US-7943776-B2 | Amide derivatives bearing a cyclopropylaminoacarbonyl substituent useful as cytokine inhibitors | ASRAZENECA AB (SE) | 2011-05-17 | — | — | US | disclosed |
| CN-101983191-A | Oxim derivatives as hsp90 inhibitors | TAKEDA PHARMACEUTICAL | 2011-03-02 | — | — | CN | disclosed |
| CN-1918134-B | Amide derivatives with cyclopropylaminocarbonyl substituents as cytokine inhibitors | ASTRAZENECA AB (SE) | 2010-11-10 | — | — | CN | disclosed |
| US-20070135440-A1 | Amide derivatives bearing a cyclopropylaminoacarbonyl substituent useful as cytokine inhibitors | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | US | disclosed |
| CN-1918134-A | Amide derivatives with cyclopropylaminocarbonyl substituents as cytokine inhibitors | ASTRAZENECA AB (SE) | 2007-02-21 | — | — | CN | disclosed |
| EP-0490323-B1 | Imidazolidine derivatives, preparation thereof, insecticides containing same as an effective ingredient and intermediates therefor | MITSUI TOATSU CHEMICALS (JP) | 1996-05-01 | — | — | EP | disclosed |
| US-5219868-A | Insecticides | MITSUI TOATSU CHEMICALS, INC. (JP) | 1993-06-15 | — | — | US | disclosed |
| EP-0490323-A1 | Imidazolidine derivatives, preparation thereof, insecticides containing same as an effective ingredient and intermediates therefor | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1992-06-17 | — | — | EP | disclosed |