Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.54 |
| ▸ | BTK | Q06187 | 2/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL270738 | 0.84 | BRD4 (0.61) | BRD4BTKSTK17AAXLTYRO3 | |
| SCHEMBL22511632 | 0.83 | PDGFRB (0.65) | BRD4STK17AJAK2JAK3JAK1 | |
| Hydrochloric Acid SCHEMBL267077 | 0.83 | BRD4 (0.60) | BRD4BTKSTK17AAXLTYRO3 | |
| SCHEMBL30459516 | 0.81 | BRD4 (0.65) | BRD4BTKSTK17AAXLMERTK | |
| SCHEMBL24327155 | 0.81 | BRD4 (0.65) | BRD4BTKSTK17AAXLMERTK | |
| SCHEMBL17915902 | 0.78 | SYK (0.49) | BRD4BTKAXLTYRO3MERTK | |
| SCHEMBL264050 | 0.76 | BRD4 (0.66) | BRD4EGFRJAK2JAK3JAK1 | |
| SCHEMBL14536087 | 0.76 | BRD4 (0.75) | BRD4JAK2JAK3JAK1BRD2 | |
| SCHEMBL270249 | 0.75 | BRD4 (0.47) | BRD4BTKAXLTYRO3MERTK | |
| SCHEMBL310838 | 0.75 | CACNA2D1 (0.49) | BRD4BTKSTK17AAXLTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022068933-A1 | COMPOUNDS AND METHODS OF TREATING DISEASES | CULLGEN (SHANGHAI) , INC. (CN) | 2022-04-07 | — | — | WO | disclosed |