Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.68 |
| ▸ | FLT1 | P17948 | 4/20 | 0.68 |
| ▸ | FLT4 | P35916 | 4/20 | 0.68 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432219 | 0.81 | KDR (0.70) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2434062 | 0.81 | KDR (1.00) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2436197 | 0.81 | KDR (0.67) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2435774 | 0.80 | KDR (0.68) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2434146 | 0.80 | KDR (0.68) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2439217 | 0.79 | KDR (0.66) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2709142 | 0.78 | PTPN1 (0.45) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2434221 | 0.77 | KDR (0.77) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2439125 | 0.74 | KDR (0.62) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL987105 | 0.74 | RXFP1 (0.72) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |