Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24334441 | 0.92 | MAPT (0.48) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL24334306 | 0.89 | GAA (0.42) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL29469699 | 0.88 | GAA (0.40) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL24333686 | 0.88 | GAA (0.41) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL24333782 | 0.88 | GAA (0.41) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL24334435 | 0.88 | GAA (0.41) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL24334290 | 0.87 | GAA (0.41) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL24333671 | 0.87 | GAA (0.41) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL29469657 | 0.87 | GAA (0.41) | NPC1RAB9AKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL24334431 | 0.86 | GAA (0.40) | NPC1RAB9AKMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |