Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 18/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.63 |
| ▸ | FGFR2 | P21802 | 9/20 | 0.63 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.63 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.63 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16674570 | 1.00 | FGFR4 (0.63) | FGFR4FGFR1FGFR2FGFR3CYP2C9 | |
| SCHEMBL21910317 | 0.99 | FGFR4 (0.62) | FGFR4FGFR1FGFR2FGFR3CYP2C9 | |
| SCHEMBL16683516 | 0.99 | FGFR4 (0.62) | FGFR4FGFR1FGFR2FGFR3CYP2C9 | |
| SCHEMBL23998140 | 0.99 | FGFR4 (0.62) | FGFR4FGFR1FGFR2FGFR3CYP2C9 | |
| SCHEMBL16674560 | 0.98 | FGFR4 (0.63) | FGFR4FGFR1FGFR2FGFR3CYP2C9 | |
| SCHEMBL16674555 | 0.96 | FGFR4 (0.64) | FGFR4FGFR1FGFR2FGFR3CYP2C9 | |
| SCHEMBL16674546 | 0.91 | FGFR4 (0.54) | FGFR4FGFR1FGFR2FGFR3CYP2C9 | |
| SCHEMBL16674582 | 0.91 | FGFR4 (0.62) | FGFR4FGFR1FGFR2FGFR3CYP2C9 | |
| SCHEMBL24335906 | 0.91 | FGFR4 (0.62) | FGFR4FGFR1FGFR2FGFR3CYP2C9 | |
| SCHEMBL16674680 | 0.90 | FGFR4 (0.57) | FGFR4FGFR1FGFR2FGFR3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3395814-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2022-04-06 | — | — | EP | disclosed |