Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.57 |
| ▸ | FLT1 | P17948 | 6/20 | 0.57 |
| ▸ | FLT4 | P35916 | 5/20 | 0.57 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432219 | 0.86 | KDR (0.70) | KDRFLT1FLT4P2RX1RET | |
| SCHEMBL2430996 | 0.82 | KDR (0.71) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2748558 | 0.76 | KDR (0.56) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL4548924 | 0.76 | KDR (0.71) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2439076 | 0.75 | KDR (0.68) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2435108 | 0.74 | PTPN1 (0.49) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2472795 | 0.74 | KDR (0.80) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2747755 | 0.73 | KDR (0.70) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2434062 | 0.73 | KDR (1.00) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2468937 | 0.72 | KDR (0.66) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |