Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dinoprostone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 known ✓ | P35408 | 5/20 | 1.00 |
| ▸ | PTGER2 known ✓ | P43116 | 4/20 | 1.00 |
| ▸ | PTGER3 known ✓ | P43115 | 4/20 | 1.00 |
| ▸ | PTGER1 known ✓ | P34995 | 3/20 | 1.00 |
| ▸ | PTGIR | P43119 | 6/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | PTGFR | P43088 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ESR1 | P03372 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dinoprostone SCHEMBL23909398 | 1.00 | PTGIR (1.00) | PTGIRPTGER4PTGER2PTGER3TSHR | |
| Dinoprostone SCHEMBL23353214 | 1.00 | PTGIR (1.00) | PTGIRPTGER4PTGER2PTGER3TSHR | |
| Dinoprostone SCHEMBL23352922 | 1.00 | PTGIR (1.00) | PTGIRPTGER4PTGER2PTGER3TSHR | |
| Dinoprostone SCHEMBL23352614 | 1.00 | PTGIR (1.00) | PTGIRPTGER4PTGER2PTGER3TSHR | |
| Dinoprostone SCHEMBL24223591 | 1.00 | PTGIR (1.00) | PTGIRPTGER4PTGER2PTGER3TSHR | |
| Dinoprostone SCHEMBL24727254 | 1.00 | PTGIR (1.00) | PTGIRPTGER4PTGER2PTGER3TSHR | |
| Dinoprostone SCHEMBL23352819 | 1.00 | PTGIR (1.00) | PTGIRPTGER4PTGER2PTGER3TSHR | |
| Dinoprostone SCHEMBL23352791 | 1.00 | PTGIR (1.00) | PTGIRPTGER4PTGER2PTGER3TSHR | |
| Dinoprostone SCHEMBL23352988 | 1.00 | PTGIR (1.00) | PTGIRPTGER4PTGER2PTGER3TSHR | |
| Dinoprostone SCHEMBL21374367 | 1.00 | PTGIR (1.00) | PTGIRPTGER4PTGER2PTGER3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057734-A1 | KEY INTERMEDIATE FOR SYNTHESIZING PROSTAGLANDIN COMPOUNDS AND PREPARATION METHOD THEREFOR | 凯特立斯（深圳）科技有限公司 | 2022-03-24 | — | — | WO | disclosed |