Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.57 |
| ▸ | FLT1 | P17948 | 3/20 | 0.57 |
| ▸ | FLT4 | P35916 | 3/20 | 0.57 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | WRN | Q14191 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273411 | 0.83 | KDR (0.57) | KDRFLT1FLT4GRM4LMNA | |
| SCHEMBL272703 | 0.82 | KDR (0.57) | KDRFLT1FLT4GRM4PDGFRB | |
| SCHEMBL273217 | 0.82 | KDR (0.68) | KDRFLT1FLT4GRM4PDGFRB | |
| SCHEMBL274571 | 0.81 | KDR (0.56) | KDRFLT1FLT4GRM4PDGFRB | |
| SCHEMBL27484180 | 0.80 | GRM4 (0.50) | KDRFLT1FLT4GRM4SMN1; SMN2 | |
| SCHEMBL272870 | 0.79 | KDR (0.58) | KDRFLT1FLT4GRM4PDGFRB | |
| SCHEMBL4981328 | 0.76 | KDR (0.71) | KDRFLT1FLT4GRM4ABL1 | |
| SCHEMBL3119134 | 0.74 | KDR (0.80) | KDRFLT1FLT4GRM4ABL1 | |
| SCHEMBL2435177 | 0.74 | KDR (0.64) | KDRFLT1FLT4GRM4PDGFRB | |
| SCHEMBL4016130 | 0.74 | KDR (0.68) | KDRFLT1FLT4GRM4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |